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Hiroyuki Watanabe Selected Research

preproenkephalin

1/2018Neuronal Expression of Opioid Gene is Controlled by Dual Epigenetic and Transcriptional Mechanism in Human Brain.
6/2017Neuropeptide imaging in rat spinal cord with MALDI-TOF MS: Method development for the application in pain-related disease studies.
9/2015Elevated mutant dynorphin A causes Purkinje cell loss and motor dysfunction in spinocerebellar ataxia type 23.
7/2013Identification and characterization of novel PDYN mutations in dominant cerebellar ataxia cases.
6/2012Non-opioid nociceptive activity of human dynorphin mutants that cause neurodegenerative disorder spinocerebellar ataxia type 23.
7/2011Prodynorphin CpG-SNPs associated with alcohol dependence: elevated methylation in the brain of human alcoholics.
4/2011Prodynorphin promoter SNP associated with alcohol dependence forms noncanonical AP-1 binding site that may influence gene expression in human brain.
11/2010Prodynorphin mutations cause the neurodegenerative disorder spinocerebellar ataxia type 23.
8/2006Preproenkephalin hypermethylation in the pure pancreatic juice compared with p53 mutation in the diagnosis of pancreatic carcinoma.

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Hiroyuki Watanabe Research Topics

Disease

49Neoplasms (Cancer)
06/2022 - 01/2003
28Alzheimer Disease (Alzheimer's Disease)
10/2021 - 05/2005
19Schizophrenia (Dementia Praecox)
01/2021 - 06/2003
14Heart Failure
12/2021 - 03/2009
14Pain (Aches)
01/2021 - 11/2004
13Amyloid Plaque
11/2020 - 09/2010
11Pancreatic Neoplasms (Pancreatic Cancer)
01/2021 - 01/2003
11Psychotic Disorders (Schizoaffective Disorder)
12/2017 - 04/2013
10Type 2 Diabetes Mellitus (MODY)
11/2021 - 05/2004
9Treatment-Resistant Schizophrenia
01/2021 - 04/2013
8Thrombosis (Thrombus)
05/2022 - 01/2006
8Inflammation (Inflammations)
01/2022 - 12/2002
8Aortic Valve Stenosis (Aortic Stenosis)
10/2020 - 07/2013
7Hypertension (High Blood Pressure)
03/2022 - 01/2012
7Atrial Fibrillation
08/2021 - 02/2009
7Cardiomegaly (Heart Hypertrophy)
01/2020 - 03/2007
6Carcinoma (Carcinomatosis)
06/2022 - 01/2002
6Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2021 - 12/2011
6Prostatic Neoplasms (Prostate Cancer)
01/2021 - 01/2016
6Coronary Artery Disease (Coronary Atherosclerosis)
01/2014 - 12/2004
5Parkinson Disease (Parkinson's Disease)
01/2022 - 01/2017
5Dementia (Dementias)
01/2022 - 01/2004
5Pathologic Constriction (Stenosis)
10/2020 - 01/2005
5Cardiovascular Diseases (Cardiovascular Disease)
01/2019 - 04/2002
5Hypertrophy
01/2019 - 12/2007
5Obesity
05/2012 - 05/2005
4Ischemia
05/2022 - 08/2002
4Infections
05/2022 - 11/2019
4Neurodegenerative Diseases (Neurodegenerative Disease)
01/2022 - 11/2010
4Brain Injuries (Brain Injury)
10/2021 - 01/2020
4Atherosclerosis
06/2019 - 01/2006
4Heart Diseases (Heart Disease)
07/2016 - 02/2009
4Cognitive Dysfunction
01/2016 - 05/2008
4Spinocerebellar Ataxias (Spinocerebellar Ataxia)
09/2015 - 11/2010
4Major Depressive Disorder (Major Depressive Disorders)
01/2015 - 07/2003
4Peritonitis
10/2008 - 11/2004
3Carcinoma in Situ
06/2022 - 01/2017
3Drug-Related Side Effects and Adverse Reactions
05/2022 - 01/2019
3Hepatocellular Carcinoma (Hepatoma)
03/2022 - 10/2009
3Insulinoma
01/2022 - 08/2011
3Disease Progression
01/2022 - 05/2009
3Multiple System Atrophy
01/2022 - 12/2020
3Hypoxia (Hypoxemia)
01/2021 - 01/2018
3Rheumatoid Arthritis
01/2021 - 05/2008

Drug/Important Bio-Agent (IBA)

24Amyloid (Amyloid Fibrils)IBA
11/2020 - 01/2011
15Proteins (Proteins, Gene)FDA Link
01/2021 - 01/2003
14Biomarkers (Surrogate Marker)IBA
09/2021 - 06/2003
12Pharmaceutical PreparationsIBA
03/2022 - 06/2003
11Dopamine (Intropin)FDA LinkGeneric
12/2017 - 04/2013
10Peptides (Polypeptides)IBA
01/2019 - 10/2009
10Antipsychotic Agents (Antipsychotics)IBA
12/2017 - 11/2003
9Biological ProductsIBA
12/2020 - 04/2004
9preproenkephalinIBA
01/2018 - 08/2006
8AntigensIBA
01/2021 - 04/2004
7Opioid Analgesics (Opioids)IBA
10/2021 - 06/2012
7Carbonic Anhydrase IXIBA
01/2021 - 01/2018
6Immune Checkpoint InhibitorsIBA
01/2022 - 01/2019
6Messenger RNA (mRNA)IBA
08/2020 - 05/2005
6SteroidsIBA
01/2020 - 01/2005
6EnzymesIBA
01/2020 - 01/2003
6Dynorphins (Dynorphin)IBA
01/2018 - 11/2010
5SynucleinsIBA
01/2022 - 01/2017
5AnticoagulantsIBA
08/2021 - 01/2010
5tau Proteins (tau Protein)IBA
05/2021 - 09/2016
5Opioid Peptides (Opioid Peptide)IBA
01/2018 - 07/2013
4CytokinesIBA
01/2022 - 11/2004
4Adrenal Cortex Hormones (Corticosteroids)IBA
01/2022 - 01/2005
4LipidsIBA
12/2020 - 06/2004
4Islet Amyloid PolypeptideIBA
11/2020 - 08/2014
4Monoclonal AntibodiesIBA
10/2020 - 01/2003
4Angiotensin IIIBA
01/2020 - 03/2007
44,4- difluoro- 4- bora- 3a,4a- diaza- s- indacene (BODIPY)IBA
06/2019 - 04/2012
4benzofuranIBA
05/2018 - 01/2013
4C-Reactive ProteinIBA
04/2016 - 10/2010
4oxidized low density lipoproteinIBA
04/2016 - 01/2006
4Risperidone (Risperdal Consta)FDA LinkGeneric
01/2016 - 04/2013
4Thallium-201IBA
06/2013 - 03/2004
4Glucose (Dextrose)FDA LinkGeneric
01/2013 - 05/2004
4Brain-Derived Neurotrophic Factor (BDNF)IBA
01/2012 - 07/2003
4Amyloid beta-PeptidesIBA
07/2010 - 03/2009
4DiglyceridesIBA
01/2007 - 03/2005
3LigandsIBA
01/2022 - 01/2015
3AcidsIBA
01/2022 - 11/2019
3NeuropeptidesIBA
05/2021 - 09/2015
3Therapeutic UsesIBA
01/2021 - 01/2018
3imidazothiadiazoleIBA
01/2021 - 01/2020
3SulfonamidesIBA
01/2021 - 01/2020
3GemcitabineFDA Link
01/2021 - 10/2008
3DiureticsIBA
11/2020 - 09/2007
3Trastuzumab (Herceptin)FDA Link
10/2020 - 01/2017

Therapy/Procedure

48Therapeutics
05/2022 - 05/2002
17Drug Therapy (Chemotherapy)
05/2022 - 01/2007
7Stents
11/2021 - 09/2007
6Transcatheter Aortic Valve Replacement
12/2019 - 07/2013
4Percutaneous Coronary Intervention
10/2018 - 09/2007
4Ligation
01/2018 - 11/2004
4Injections
01/2016 - 04/2013
3Precision Medicine
06/2021 - 01/2018
3Intravenous Injections
01/2021 - 07/2012
3Catheters
11/2020 - 01/2016